FACTOR VIII

Hemophilia A (Factor VIII deficiency) is the most common severe congenital bleeding X-linked disorder affecting 1:5000 to 10,000 males. Females are usually carriers but can have Hemophilia A if there is imbalanced Lyonization of the normal X-chromosome, Turner’s syndrome or daughters of an affected male and a carrier female. The disease is characterized by hemarthrosis, soft tissue hematomas, easy bruising, excessive bleeding during surgery, dental extraction and poor wound healing.