APOLIPOPROTEIN A1 (APO A)

Apolipoprotein A-I is a relatively abundant plasma protein and is encoded by the APOA1 gene. It is the major protein component of HDL (High-density lipoprotein) or ‘good cholesterol’ and has a specific role in lipid metabolism and anticlotting effect of the body. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.